A Brief History of Antibodies

The acquisition of immunity to the diseases the patient has been dealing with has been documented for centuries. Some of the earliest work in the field now known as immunology was carried out between 1714 and 1717. Lady Mary Wortley Montague, Emmanuel Timoni, and James Pilarini pioneered smallpox vaccination, an unprecedented medical practice.

Variolation is known to use live smallpox virus in fluid taken from the smallpox bladder and carried briefly in cases of mild disease. In 1798, the smallpox vaccination was first demonstrated more prominently by Edward Jenner. You can easily visit www.bosterbio.com/services/custom-antibody-production-services to get antibody production services.

It does this by vaccinating the boy with smallpox pustule fluid, which gives him immunity to the very similar, but much more serious, disease of smallpox.

Image Source: Google

The earliest mention of antibodies came from Emil von Bering and Shibasabura Kitasato in 1890. In their famous publication, they demonstrated that the transfer of serum from animals immunized against diphtheria to infected animals could cure the animal. The potential for human medicine was immediately apparent, and Bering was awarded the Nobel Prize in 1901 for this work.

In 1900 Paul Ehrlich, who is considered one of the fathers of modern immunology, proposed the side-chain theory, in which he hypothesized that side-chain receptors on cells bind to pathogens.

He was the first to propose a model for an antibody molecule, in which an antibody is branched and composed of multiple sites to bind to a foreign material known as an antigen and activate the complement pathway. This model agrees with the "lock-and-lock" enzyme hypothesis proposed by Emil Fischer and is still largely true today.